Synthesis of quinazolinones recent literature an acceptorless coupling of o -aminobenzamides with methanol has been accomplished in the presence of the metal-ligand bifunctional catalyst [cpir(2,2′-bpyo)(h 2 o)] to provide quinazolinones in good yields. General procedure for synthesis of 2-aryl quinazolinones and 5-substituted pyrazolo[4,3-d]pyrimidine-7-one: to a solution of 2-aminobenzamide (1470 mmol, 10 eq) was added to a solution of terminal alkyne (1470 mmol, 10 eq), tosyl azide, (1470 mmol, 10 eq), cui (0147 mmol, 01 eq), triethylamine (2941 mmol, 20 eq), in acetonitrile (10 ml) under n 2 atmosphere.
A novel synthesis of 3-substituted 4(3h)-quinazolinones via hatu-mediated coupling of 4-hydroxyquinazolines with primary amines has been developed under mild reaction conditions, the products were achieved in good yield from commercially available starting materials. 1-substitued-2-chloromethyl-4 (1h)- quinazolinones (iii) were synthesized in good yields by the reaction of 2-phenylaminobenzamide with excess of acid chloride under mild conditions the compounds were characterized by physical data, ir and nmr analysis.
A series of 2′,3′,4′,6,7-substituted 2-aryl quinazolinones were synthesized and evaluated for biological activity among them, 17 displayed significant growth inhibitory action against a panel of tumor cell lines. Treatment of various substituted acetylated quinazolinones with benzaldehyde lead to 18 substituted quinazolinonyl chalcones respectively further, when the chalcones were treated with thiosemicarbazide and nh 2 ohhcl lead to synthesis of a total of 36 compounds with complex quinazolinonyl thiocarbamoyl pyrazolines and quinazolinonyl isoxazoles. Synthesis, molecular docking and biological evaluation of substituted quinazolinones as antibacterial agents arun mahato 1 , birendra shrivastava 2 and nithya shanthi 1.
Rajput cs, kumar s, kumar a synthesis and antifungal activity of substituted quinazolinones int j chem tech res 2010 2(3):1653 mosaad sm, mohammed ki, ahmed ma, hamide sga. Request article pdf | synthesis of quinazolinones and quinazolines | citations: 139 | synthetic methods for the construction of the 4(3h)-quinazolinone 1 and quinazoline 2 skeletons, with a particular emphasis on the 2-substituted and 2,4-disubstituted analogues, are reviewed.
Abstract: a novel and efficient cu(i)-catalyzed ligand- and base-free multipathway domino strategy has been developed for the synthesis of 2-substituted quinazolinones the reaction utilizes 2-bromobenzamide and multiform substrates such as aldehydes, alcohols, and. A range of 2-aryl and 2-alkyl quinazolinones have been prepared in moderate to good yields from the reaction of anthranilic acid and the appropriately substituted imidate in a facile, mild, onepot.
A cu (no3)23h2o catalysed facile synthesis of substituted 4(3h)-quinazolinones and benzimidazoles g a n k durgareddy b , r ravikumar a,∗ ,sravi b and srinivas r adapa c.